We recently had a Microsoft update and after that our users were not able to open some documents in SAP portal screens. Upon checking we found that the issue is only with Microsoft Edge 64 bit and Chrome. Firefox and Microsoft Edge 32 bit is working fine. Following is the fix and the relevant notes.

Issue: Windows update caused some SAP(and possibly other application) links not working
Solution:
       a) On registry create the following entry
          Windows registry location: HKEY_LOCAL_MACHINE-
          Software\Policies\Google\Chrome\OriginAgentClusterDefaultEnabled
          Set Value : 0x00000000
       b) Changes on browser configuration
          Go to URL edge://flags
          Search for "Origin keyed Agent Clusters by default"
          Set it to Disabled
          Relaunch browser

What is needed  ? Please test the registry updates and browser changes on affected desktops.
References :
Chrome Enterprise Policy List & Management | Documentation
0003369675 – FAQ: Enterprise Portal inner application navigation issues with Google Chrome Version starting 115/116 & Edge Version starting 118/119

SAP OSS message reply on this

This is a known issue and this issue is due to a change performed by Google Chrome on domain relaxation mechanism :

With version 115/116 the Chrome browser wants to restrict by default access to document.domain which has been used to relax the same-origin policy
For more information about Google Chrome and ‘Origin-Agent-Cluster’ please read the corresponding Google Chrome pages.

https://developer.chrome.com/blog/immutable-document-domain/
https://chromeenterprise.google/policies/#OriginAgentClusterDefaultEnabledEmbedding

Please refer to Note 0003159245 – Google Chrome disables domain relaxation starting M109  for the resolution of the issue.
You could try either of the option you wish.
If you wish proceed with Option 2, then both steps involved have to be applied together !

In addition, we also have a KBA ready to serve regarding questions you may have during applying above fixing note:
0003369675 – FAQ: Enterprise Portal inner application navigation issues with Google Chrome Version starting 115/116 & Edge Version starting 118/119

For more information about Microsoft Edge will disable modifying document.domain, please refer to Microsoft page:
https://learn.microsoft.com/en-us/deployedge/edge-learnmore-origin-keyed-agent-cluster#browser-compatibility

This is what should be done from Windows registry based on information provided by Microsoft in case you would like to fix this issue by performing change from Windows Registry level:
https://learn.microsoft.com/en-us/deployedge/microsoft-edge-policies#originagentclusterdefaultenabled